INT. J. CANCER. 2010 JAN 1,; 126(1):171-9.
Animal Models have demonstrated inhibition of prostate cancer by downregulation of androgen receptors.
This study investigated whether red wine consumption reduces the risk of prostate cancer.
-a Kaiser questionnaire study
-84,170 male participants ages 45-69: 40% minority, controlled for race,
income, BMI, meat consumption, family history, history of STIs, Benign prostatic hypertrophy or prostate surgery.
-stratified into <1D/w, >1D/w but <1D/d, or >1D/d
Red wine associated with-healthier lifestyle, better diet
Consumers less likely to be smokers.
Consumers are more likely to be screen for PSA.
Consumption not associated with prostate cancer.
Consumption did not validate prior inverse association.
Inverse relationship was seen in consumers who had psa done.
No long term data.
Current "non-users" could have once been users.
Human studies have shown resveratrol the presumed active agent is conjugated quickly in metabolism. It fails to achieve significant concentration in the prostate, therefore, the presumed mechanism of action is unclear.